AC-42
AC-42 is a poent M1 muscarinic selective allosteric agonist with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 stimulates the IP-accumulation and calcium mobilization in CHO cells[1][2].
Product Specifications
CAS Number
244291-63-2
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ac-42.html
Solubility
10 mM in DMSO
Smiles
O=C(CCCN1CCC(CC1)CCCC)C2=CC=CC=C2C
Molecular Formula
C20H31NO
Molecular Weight
301.47
References & Citations
[1]Marlene A Jacobson, et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'- (2-methylbenzyl) -1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site. Mol Pharmacol. 2010 Oct;78 (4) :648-57.|[2]Langmead CJ, et al., Probing the molecular mechanism of interaction between 4-n-butyl-1-[4- (2-methylphenyl) -4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M (1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Mol Pharmacol. 2006 Jan;69 (1) :236-46.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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