KMN-80
Product Specifications
CAS Number
1628759-75-0
UNSPSC Description
KMN-80, a derivative of PGE1 (HY-B0131), is a selective and potent agonist of EP4 receptor with an IC50 and a Ki of 3 nM and 2.35 nM, respectively. KMN-80 is against EP3 receptor with an IC50 of 1.4 μM and >10 μM for all other prostanoid receptors[1]. KMN-80 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/kmn-80.html
Solubility
10 mM in DMSO
Smiles
OC(CCCCCCN(C1=O)[C@H](CC1)/C=C/[C@@H](O)[C@@H](C)CC#CCC)=O
Molecular Weight
363.49
References & Citations
[1]M Li, et al. Prostaglandin E(2) Receptors in Bone Formation. Int Orthop|[2]Thomas A Owen, et al. KMN-159, a Novel EP 4 Receptor Selective Agonist, Stimulates Osteoblastic Differentiation in Cultured Whole Rat Bone Marrow. Gene. 2020 Jul 20;748:144668.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Frequently Asked Questions
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