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BMH-22

BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1].

Product Specifications

CAS Number

309726-06-5

UNSPSC

12352005

Hazard Statement

H314

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bmh-22.html

Purity

98.85

Solubility

DMSO : 4.17 mg/mL (ultrasonic)

Smiles

CC1=C2N=C3N=C(C=C(C3=C(C2=CC(C)=C1)N)C)C

Molecular Formula

C16H17N3

Molecular Weight

251.33

Precautions

H314

References & Citations

[1]RPA194, rRNA synthesis, 45S Rrna, anticancer Karita Peltonen, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014 Nov;13 (11) :2537-46.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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