BMH-22
BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1].
Product Specifications
CAS Number
[309726-06-5]
UNSPSC
12352005
Hazard Statement
H314
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bmh-22.html
Purity
98.85
Solubility
DMSO : 4.17 mg/mL (ultrasonic)
Smiles
CC1=C2N=C3N=C(C=C(C3=C(C2=CC(C)=C1)N)C)C
Molecular Formula
C16H17N3
Molecular Weight
251.33
Precautions
H314
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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