SAR629

SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation[1][2].

Product Specifications

CAS Number

[1221418-42-3]

UNSPSC

12352005

Target

MAGL

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sar629.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1N=CN=C1)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F

Molecular Formula

C20H19F2N5O

Molecular Weight

383.39

References & Citations

[1]Niina Aaltonen, et al. Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem Biol. 2013 Mar 21;20 (3) :379-90.|[2]T Bertrand, et al. Structural basis for human monoglyceride lipase inhibition. J Mol Biol. 2010 Feb 26;396 (3) :663-73.