Eucannabinolide
Eucannabinolide is a STAT3 inhibitor. Eucannabinolide suppresses STAT3 activation at tyrosine 705, inhibiteds its translocation to nucleus, and decreases its DNA binding capacity. Eucannabinolide can be used for triple negative breast cancer (TNBC) diseases research[1].
Product Specifications
CAS Number
38458-58-1
Product Name Alternative
Hiyodorilactone A; Schkuhrin I
UNSPSC
12352005
Target
STAT
Type
Natural Products
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eucannabinolide.html
Purity
93.53
Solubility
10 mM in DMSO
Smiles
C/C(C[C@H]1OC(/C(CO)=C/CO)=O)=C/C[C@H](OC(C)=O)/C(C)=C\[C@@]([C@]1([H])C2=C)([H])OC2=O
Molecular Formula
C22H28O8
Molecular Weight
420.45
References & Citations
[1]Zhu Z, et al. Eucannabinolide, a novel sesquiterpene lactone, suppresses the growth, metastasis and BCSCS-like traits of TNBC via inactivation of STAT3. Neoplasia. 2021 Jan;23 (1) :36-48.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
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