ICRF-196
Product Specifications
UNSPSC Description
ICRF-196 is an racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193 (HY-118590). ICRF-193 is an TopoII inhibitor. ICRF-196 can be used for the research of cancer[1].
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/icrf-196.html
Solubility
10 mM in DMSO
Smiles
CC(N(C1)CC(NC1=O)=O)C(N(C2)CC(NC2=O)=O)C
Molecular Weight
282.30
References & Citations
[1]Snapka RM,et al. Inhibition of topoisomerase II by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane. Critical dependence on 2,3-butanediyl linker absolute configuration. Biochem Pharmacol. 1996;52(4):543-549.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118590A/ICRF-196-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118590A/
Clinical Information
No Development Reported
CAS Number
21416-68-2
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