TP0427736

TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells[1].

Product Specifications

CAS Number

[864374-00-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tp0427736.html

Solubility

10 mM in DMSO

Smiles

CC1=CSC(C2=C(NC=N2)C3=CC=C4N=CSC4=C3)=N1

Molecular Formula

C14H10N4S2

Molecular Weight

298.39

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Naruse T, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-βinduced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 Jun;69 (3) :485-491.