Platencin

Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis. Platencin inhibits β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively) with IC50s of 1.95 and 3.91 μg/ml, respectively[1].

Product Specifications

CAS Number

[869898-86-2]

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/platencin.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C[C@]2(CC3)CC([C@@]3(C[C@]2([C@@]1(CCC(NC4=C(C(C(O)=O)=CC=C4O)O)=O)C)[H])[H])=C

Molecular Formula

C24H27NO6

Molecular Weight

425.47

References & Citations

[1]Wang J, et al. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc Natl Acad Sci U S A. 2007 May 1;104 (18) :7612-6.