Sphingosine (d14:1)
Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG) /Phorbol esters[1].
Product Specifications
CAS Number
[24558-60-9]
Product Name Alternative
Tetradecasphing-4-enine
UNSPSC
12352211
Target
PKC
Type
Natural Products
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sphingosine-d14-1.html
Purity
99.69
Solubility
10 mM in DMSO
Smiles
OC[C@@H]([C@@H](/C=C/CCCCCCCCC)O)N
Molecular Formula
C14H29NO2
Molecular Weight
243.39
References & Citations
[1]Y A Hannun, et al. Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15;185 (3) :333-45.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PKC
Curated Selection
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