JNJ-55511118
JNJ-55511118 is a highly potent, reversible, and selective AMPA receptor inhibitor selective for TARP-γ8. JNJ-55511118 fully displaces the radioligand (20 nM) with the Ki of 26 nM in competition binding experiments. JNJ-55511118 is a tool molecule with potential therapeutic utility as an anticonvulsant or neuroprotectant[1].
Product Specifications
CAS Number
[2036081-86-2]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnj-55511118.html
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1NC2=C(N1)C=C(C3=C(OC(F)(F)F)C=CC=C3Cl)C=C2
Molecular Formula
C14H8ClF3N2O2
Molecular Weight
328.67
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor
Available Sizes
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