PD 119819
PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis[1][2].
Product Specifications
CAS Number
105277-43-8
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pd-119819.html
Solubility
10 mM in DMSO
Smiles
O=C1C=COC2=CC(OCCCN3CCN(CC3)C4=NC=CC=C4)=CC=C12.[H]Cl.[H]Cl
Molecular Formula
C21H25Cl2N3O3
Molecular Weight
438.35
References & Citations
[1]Macallum GE, et al. Renal and hepatic toxicity of a benzopyran-4-one in the Cynomolgus monkey. Toxicology. 1989;59 (1) :97-108.|[2]Jaen JC, et al. Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy) -4H-1-benzopyran-4-ones. J Med Chem. 1991;34 (1) :248-256.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Dopamine Receptor
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