AS604872

AS604872 is an orally active, potent and selective prostaglandin F2α receptor (FP) antagonist with a Ki of 35 nM in humans, 158 nM in rats and 323 nM in mice. AS604872 inhibits contractions and delays labour[1].

Product Specifications

CAS Number

[612532-48-6]

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/as604872.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1N(CCS1)S(=O)(C2=CC=C(C3=CC=CC=C3)C=C2)=O)N[C@@H](C4=CC=CC=N4)C5=CC=CC=C5

Molecular Formula

C28H25N3O3S2

Molecular Weight

515.65

References & Citations

[1]Rocco Cirillo, et al. Arrest of preterm labor in rat and mouse by an oral and selective nonprostanoid antagonist of the prostaglandin F2alpha receptor (FP) . Am J Obstet Gynecol. 2007 Jul;197 (1) :54.e1-9.