NSC 140873
NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335) [1][2].
Product Specifications
CAS Number
106410-13-3
UNSPSC
12352005
Target
RUNX
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/nsc-140873.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(C(C2=CC=CN2)=O)=C(NC(CN)=O)C=C1
Molecular Formula
C13H12ClN3O2
Molecular Weight
277.71
References & Citations
[1]Pu Liu, et al. Methods for treating leukemia and disorders mediated by cbfβ and runx1 proteins. Patent. WO2012125787A1. |[2]Cunningham L, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A. 2012 Sep 4;109 (36) :14592-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
E-UNEL-R0029-01 5x 96 Tests
Uncoated Rat IL-2 (Interleukin 2) ELISA Kit
Sign In for Pricing
View Details E-UNEL-R0029-02 15x 96 Tests
Uncoated Rat IL-2 (Interleukin 2) ELISA Kit
Sign In for Pricing
View Details 
PKSH032702-01 10 µg
Recombinant Human LMIR2/CD300C Protein (Fc Tag)
Sign In for Pricing
View Details PKSH032702-02 50 µg
Recombinant Human LMIR2/CD300C Protein (Fc Tag)
Sign In for Pricing
View Details