PF-4479745
PF-4479745 is a potent and selective 5-HT2C receptor agonist (EC50: 10 nM, ki: 15 nM) . PF-4479745 can be used in the research of cardiovascular disease like hypertension[1].
Product Specifications
CAS Number
1065110-43-1
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pf-4479745.html
Solubility
10 mM in DMSO
Smiles
CNC1=C2C([C@H](CNCC2)C)=NC(CC3=CC=CC=C3)=N1
Molecular Formula
C17H22N4
Molecular Weight
282.38
References & Citations
[1]R Ian Storer, et al. Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors. J Med Chem. 2014 Jun 26;57 (12) :5258-69.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; mLAG-3; MUC2; α-1 microglobulin
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