Hymenidin

Hymenidin is a natural antagonist of serotonergic receptor and inhibitor of voltage-gated potassium channels. Hymenidin also induces cancer cell apoptosis[1][2][3].

Product Specifications

CAS Number

[107019-95-4]

UNSPSC

12352005

Target

5-HT Receptor; Potassium Channel

Type

Natural Products

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hymenidin.html

Solubility

10 mM in DMSO

Smiles

O=C(NC/C=C/C1=CN=C(N1)N)C2=CC(Br)=CN2

Molecular Formula

C11H12BrN5O

Molecular Weight

310.15

References & Citations

[1]Kobayashi J, et al. A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp. Experientia. 1986 Oct 15;42 (10) :1176-7. |[2]Zidar N, et al. Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem. 2017 Oct 20;139:232-241. |[3]Tihomir Tomašič, et al. Analogues of the marine alkaloids oroidin, clathrodin, and hymenidin induce apoptosis in human HepG2 and THP-1 cancer cells. MedChemComm. 2015, 6 (1) : 105-110.