OSI-296
OSI-296 is a potent, oral and selective inhibitor of cMET and RON kinases. OSI-296 shows in vivo efficacy in MKN45 tumor xenografts models and well tolerated[1].
Product Specifications
CAS Number
1175296-94-2
UNSPSC
12352005
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/osi-296.html
Solubility
10 mM in DMSO
Smiles
O=C(N)N1CC=C(CC1)C2=COC3=C2C=NC(N)=C3O[C@H](C)C4=C(C=CC(F)=C4Cl)Cl
Molecular Formula
C21H19Cl2FN4O3
Molecular Weight
465.30
References & Citations
[1]Steinig AG, et al. Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases. Bioorg Med Chem Lett. 2013;23 (15) :4381-4387.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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