LSN2814617
LSN2814617 is an orally active, potent, brain-penetrant, and selective mGlu5 (metabotropic glutamate 5) positive allosteric modulator (PAM), with EC50 values of 52 nM (Human mGlu5) and 42 nM (rat mGlu5) . LSN2814617 shows wake-promoting effect. LSN2814617 can be used for schizophrenia research[1].
Product Specifications
CAS Number
1313498-17-7
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lsn2814617.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C=C1)C2=NOC([C@@H]3CC4=NN=C(N4CC3)C(C)(C)C)=N2
Molecular Formula
C18H20FN5O
Molecular Weight
341.38
References & Citations
[1]Gilmour G, et al. In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
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