(R) -Thionisoxetine
(R) -Thionisoxetine is a potent and selective inhibitor of central and peripheral norepinephrine (NE) uptake. (R) -thionisoxetine prevented hypothalamic NE depletion by 6-hydroxydopamine with an ED50 of 0.21 mg/kg. (R) -Thionisoxetine can be used for the research of a variety of diseases including depression and urinary incontinence[1].
Product Specifications
CAS Number
163059-33-4
Product Name Alternative
LY-368975
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r-thionisoxetine.html
Solubility
10 mM in DMSO
Smiles
CSC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC
Molecular Formula
C17H21NOS
Molecular Weight
287.42
References & Citations
[1]Gehlert DR, et al. (R) -thionisoxetine, a potent and selective inhibitor of central and peripheral norepinephrine uptake. Life Sci. 1995;56 (22) :1915-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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