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I-SAP

I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC) [1][2].

Product Specifications

CAS Number

[133538-58-6]

UNSPSC

12352005

Hazard Statement

H225, H319

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/i-sap.html

Solubility

10 mM in DMSO

Smiles

OC(CCC/C=C\C[C@H]1[C@@](C[C@]2([H])C[C@@H]1N[S](=O)(C(C=C3)=CC=C3I)=O)([H])C2(C)C)=O

Molecular Formula

C22H30INO4S

Molecular Weight

531.45

Precautions

H225, H319

References & Citations

[1]Saussy DL Jr, et al. Binding of a novel radioiodinated thromboxane A2/prostaglandin H2 antagonist to guinea pig lung membranes. Eicosanoids. 1992;5 (1) :1-4. |[2]Schrör K, et al. Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine. Biochem Pharmacol. 1995 Mar 30;49 (7) :921-7.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature 3 years

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-118044/I-SAP-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-118044/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TXA2/TP

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