UMB-32
UMB-32, a potent, selective BRD4 inhibitor, binds BRD4 with the Kd of 550 nM, and IC50 of 637 nM. UMB-32 also shows potency against TAF1, a bromodomain-containing transcription factor[1].
Product Specifications
CAS Number
1635437-39-6
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/umb-32.html
Purity
99.11
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(NC1=C(C2=CC=C(C=C2)C3=C(ON=C3C)C)N=C4N1C=CN=C4)C
Molecular Formula
C21H23N5O
Molecular Weight
361.44
References & Citations
[1]Michael R McKeown, et al. Biased multicomponent reactions to develop novel bromodomain inhibitors. J Med Chem. 2014 Nov 13;57 (21) :9019-27.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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