RU-505
RU-505 is an effective β-amyloid (Aβ) -fibrinogen interaction inhibitor with IC50s of 5.00 and 2.72 μM in fluorescence polarization (FP) and AlphaLISA assays, respectively. RU-505 is highly permeable to the BBB. RU-505 reduces cerebral amyloid angiopathy (CAA) . RU-505 can be used for the research of Alzheimer’s disease (AD) [1].
Product Specifications
CAS Number
1314206-29-5
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ru-505.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC2=CC(C(C)(C)C)=NN2C(C3=CC=C(F)C=C3)=C1)N(CCN(C)C)CC4=CC=CC=C4
Molecular Formula
C28H32FN5O
Molecular Weight
473.58
References & Citations
[1]Hyung Jin Ahn, et al. A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice. J Exp Med. 2014 Jun 2;211 (6) :1049-62.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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