RU-505
RU-505 is an effective β-amyloid (Aβ) -fibrinogen interaction inhibitor with IC50s of 5.00 and 2.72 μM in fluorescence polarization (FP) and AlphaLISA assays, respectively. RU-505 is highly permeable to the BBB. RU-505 reduces cerebral amyloid angiopathy (CAA) . RU-505 can be used for the research of Alzheimer’s disease (AD) [1].
Product Specifications
CAS Number
1314206-29-5
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ru-505.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC2=CC(C(C)(C)C)=NN2C(C3=CC=C(F)C=C3)=C1)N(CCN(C)C)CC4=CC=CC=C4
Molecular Formula
C28H32FN5O
Molecular Weight
473.58
References & Citations
[1]Hyung Jin Ahn, et al. A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice. J Exp Med. 2014 Jun 2;211 (6) :1049-62.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
485935 100 µL
MMP15 (Matrix Metalloproteinase-15, Matrix Metallopeptidase 15 (Membrane-Inserted) )
Sign In for Pricing
View Details 
A0760-41K 100 µL
Actin, beta (ACTB, Actin Cytoplasmic 1, Beta Cytoskeletal Actin) (Biotin)
Sign In for Pricing
View Details