Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

GGTI-286 (hydrochloride)

GGTI-286 hydrochloride, a potent GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A) . GGTI-286 hydrochloride selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively) . GGTI-286 hydrochloride also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1][2].

Product Specifications

CAS Number

[181141-66-2]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ggti-286-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O.[H]Cl

Molecular Formula

C23H32ClN3O3S

Molecular Weight

466.04

References & Citations

[1]E C Lerner, et al. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J Biol Chem. 1995 Nov 10;270 (45) :26770-3.|[2]Naoyuki Nishiya, et al. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway. Chem Biol. 2014 Apr 24;21 (4) :530-540.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Efinaconazole Impurity 67
RM-E061467-01 10 mg

Efinaconazole Impurity 67

Ask
View Details
Efinaconazole Impurity 67
RM-E061467-02 25 mg

Efinaconazole Impurity 67

Ask
View Details
Efinaconazole Impurity 67
RM-E061467-03 50 mg

Efinaconazole Impurity 67

Ask
View Details
Efinaconazole Impurity 67
RM-E061467-04 100 mg

Efinaconazole Impurity 67

Ask
View Details
Recombinant Human Calmodulin/CALM1 Protein
E53A04952 50 µg

Recombinant Human Calmodulin/CALM1 Protein

Ask
View Details
CDR2 (Cerebellar Degeneration-related Protein 2, Paraneoplastic Cerebellar Degeneration-associated Antigen, Major Yo Paraneoplastic Antigen, PCD17) (APC)
C2581-01D-APC 100 µL

CDR2 (Cerebellar Degeneration-related Protein 2, Paraneoplastic Cerebellar Degeneration-associated Antigen, Major Yo Paraneoplastic Antigen, PCD17) (APC)

Ask
View Details