(Rac) -CCT 250863
(Rac) -CCT 250863 (compound rac-21) is a selective and reversible NEK 2 inhibitor with an IC50 of 0.073 µM. (Rac) -CCT 250863 shows good effects of inducing cell cycle arrest and also can antiproliferative in cells (Pomalidomide sensitive/resistant) . (Rac) -CCT 250863 induces apoptosis when combines with Pomalidomide[1][2].
Product Specifications
CAS Number
1364269-06-6
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rac-cct-250863.html
Purity
99.50
Solubility
DMSO : 50 mg/mL (ultrasonic; warming)
Smiles
O=C(N)C1=CC=C(C2=CC(C3=CC(CN(C)C)=CS3)=CN=C2N)C=C1OC(C)/C=C\C(F)(F)F
Molecular Formula
C24H25F3N4O2S
Molecular Weight
490.54
References & Citations
[1]Ahsan A, et al. Methods for treating cancer with combination therapies. WO2021262962A1. |[2]Innocenti P, et al. Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J Med Chem. 2012 Apr 12;55 (7) :3228-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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