(Rac) -CCT 250863

(Rac) -CCT 250863 (compound rac-21) is a selective and reversible NEK 2 inhibitor with an IC50 of 0.073 µM. (Rac) -CCT 250863 shows good effects of inducing cell cycle arrest and also can antiproliferative in cells (Pomalidomide sensitive/resistant) . (Rac) -CCT 250863 induces apoptosis when combines with Pomalidomide[1][2].

Product Specifications

CAS Number

[1364269-06-6]

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rac-cct-250863.html

Purity

99.50

Solubility

DMSO : 50 mg/mL (ultrasonic; warming)

Smiles

O=C(N)C1=CC=C(C2=CC(C3=CC(CN(C)C)=CS3)=CN=C2N)C=C1OC(C)/C=C\C(F)(F)F

Molecular Formula

C24H25F3N4O2S

Molecular Weight

490.54

References & Citations

[1]Ahsan A, et al. Methods for treating cancer with combination therapies. WO2021262962A1. |[2]Innocenti P, et al. Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J Med Chem. 2012 Apr 12;55 (7) :3228-41.