KBP-7018

KBP-7018 is a tyrosine kinase-selective inhibitor. KBP-7018 has potent inhibitory effects on c-KIT, PDGFR, and RET with IC50 values of 10 nM, 7.6 nM and 25 nM, respectively. KBP-7018 can be used for the research of idiopathic pulmonary fibrosis[1].

Product Specifications

CAS Number

[1613437-66-3]

UNSPSC

12352005

Target

C-Kit; PDGFR; RET

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/kbp-7018.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC4=C(N(C(CN5CCOCC5)=O)CC4)C=C3)/C6=CC=CC=C6)OC

Molecular Formula

C31H30N4O5

Molecular Weight

538.59

References & Citations

[1]Huang Z, et al. Discovery of Indolinone-Based Multikinase Inhibitors as Potential Therapeutics for Idiopathic Pulmonary Fibrosis. ACS Med Chem Lett. 2017 Sep 30;8 (11) :1142-1147.