(R) -Pralatrexate

(R) -Pralatrexate is the (R) -enantiomer of Pralatrexate (HY-10446) . Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor[1].

Product Specifications

CAS Number

[1320211-70-8]

UNSPSC

12352005

Hazard Statement

H302-H361

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-pralatrexate.html

Solubility

10 mM in DMSO

Smiles

O=C(CC[C@H](NC(C1=CC=C(C=C1)[C@H](CC#C)CC2=NC3=C(N=C(N=C3N=C2)N)N)=O)C(O)=O)O

Molecular Formula

C23H23N7O5

Molecular Weight

477.47

Precautions

P264-P270-P280-P330-P405-P501

References & Citations

[1]Enrica Marchi, et al. Pralatrexate Is Synergistic With the Proteasome Inhibitor Bortezomib in in Vitro and in Vivo Models of T-cell Lymphoid Malignancies. Clin Cancer Res. 2010 Jul 15;16 (14) :3648-58.