OSU-2S
Product Specifications
UNSPSC Description
OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity[1][2].
Target Antigen
Apoptosis; PKC
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics;TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/osu-2s.html
Solubility
10 mM in DMSO
Smiles
CCC[C@@](CCC1=CC=C(OCCCCCC(C)C)C=C1)(N)CO
Molecular Weight
335.52
References & Citations
[1]Omar HA, et al. OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53. Front Pharmacol. 2016 Nov 30;7:463.|[2]Omar HA, et al. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology. 2011 Jun;53(6):1943-58.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117720/OSU-2S-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117720/
Clinical Information
No Development Reported
CAS Number
1351056-65-9
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