LY 292728
LY 292728 is a potent leukotriene B4 (LTB4) receptor antagonist. LY 292728 binds to human neutrophils with a Ki of 0.47 nM and binds to guinea pig lung membranes with a Ki of 0.04 nM[1].
Product Specifications
CAS Number
153034-77-6
UNSPSC
12352005
Target
Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ly-292728.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC2=C(C=C1)OC3=C(C=CC(OCCCOC4=C(C=C(C(O)=C4)C5=CC=C(C=C5)F)CC)=C3CCC(O)=O)C2=O
Molecular Formula
C34H29FO9
Molecular Weight
600.59
References & Citations
[1]Sawyer JS, et al. Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36 (24) :3982-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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