L- (+) -threo-Chloramphenicol

L- (+) -threo-Chloramphenicol ((+) -Chloramphenicol) is the S, S-stereoisomer of Chloramphenicol (HY-B0239) . L- (+) -Threo-chloramphenicol inhibits protein synthesis in reticulocytes. L- (+) -threo-Chloramphenicol also inhibits the oxidative activity of isolated mitochondria[1][2].

Product Specifications

CAS Number

[134-90-7]

Product Name Alternative

(+) -Chloramphenicol; Dextramycine; Dextromycetin

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Antibiotic

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/l-plus-threo-chloramphenicol.html

Solubility

10 mM in DMSO

Smiles

O=C(C(Cl)Cl)N[C@H]([C@H](C1=CC=C(C=C1)[N+]([O-])=O)O)CO

Molecular Formula

C11H12Cl2N2O5

Molecular Weight

323.13

Precautions

H315, H319, H320

References & Citations

[1]3rd WG, et, al. The effect of chloramphenicol in intact erythroid cells. J Mol Biol. 1966 Nov 28;21 (3) :537-53. |[2]Gordon PA, et, al. Effects of chloramphenicol isomers and erythromycin on enzyme and lipid synthesis induced by oxygen in wild-type and petite yeast. J Bacteriol. 1972 May;110 (2) :504-10.