MDL 101146
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis[1][2].
Product Specifications
CAS Number
149859-17-6
UNSPSC
12352005
Target
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mdl-101146.html
Solubility
10 mM in DMSO
Smiles
O=C(N(CCC1)[C@@H]1C(NC(C(C)C)C(C(F)(F)C(F)(F)F)=O)=O)[C@H](C(C)C)NC(C(C=C2)=CC=C2C(N3CCOCC3)=O)=O
Molecular Formula
C29H37F5N4O6
Molecular Weight
632.62
References & Citations
[1]Angelastro M, et al. Inhibition of human neutrophil elastase with peptidyl|[2]M J Janusz, et al. Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146. Inflamm Res. 1997 Dec;46 (12) :503-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
