Bisindolylmaleimide XI (hydrochloride)
Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is a potent, selective and orally active PKC inhibitor with IC50s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCε, respectively[1][2].
Product Specifications
CAS Number
145333-02-4
Product Name Alternative
Ro 32-0432; Ro 31-8830 (hydrochloride)
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bisindolylmaleimide-xi-hydrochloride.html
Purity
98.91
Solubility
DMSO : 5 mg/mL (ultrasonic; warming)
Smiles
O=C(NC1=O)C(C2=C3CC(CCN3C4=C2C=CC=C4)CN(C)C)=C1C5=CN(C6=C5C=CC=C6)C.Cl
Molecular Formula
C28H29ClN4O2
Molecular Weight
489.01
References & Citations
[1]S E Wilkinson, et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1;294 (Pt 2) (Pt 2) :335-7.|[2]A M Birchall, et al. Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J Pharmacol Exp Ther. 1994 Feb;268 (2) :922-9.|[3]Roman Kholodenko, et al. Anti-apoptotic effect of retinoic acid on retinal progenitor cells mediated by a protein kinase A-dependent mechanism. Cell Res. 2007 Feb;17 (2) :151-62.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCα; PKCβ; PKCγ; PKCε
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