L-669,262
L-669,262, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, with an IC50 of 0.10 ng/mL for rat liver HMG-CoA[1].
Product Specifications
CAS Number
130468-11-0
Product Name Alternative
6-Oxo Simvastatin; Iso-simvastatin-6-one
UNSPSC
12352005
Target
HMG-CoA Reductase (HMGCR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/l-669-262.html
Solubility
10 mM in DMSO
Smiles
CCC(C)(C(O[C@H]1CC(C)=CC2=CC([C@@H]([C@@H]([C@@]12[H])CC[C@@H]3C[C@H](CC(O3)=O)O)C)=O)=O)C
Molecular Formula
C25H36O6
Molecular Weight
432.55
References & Citations
[1]Joshua H, et, al. L-669,262, a potent HMG-CoA reductase inhibitor. J Antibiot (Tokyo) . 1991 Mar;44 (3) :366-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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