CAY10621
CAY10621 (SKI 5C; compound 5c) is a specific sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 3.3 μM. CAY10621 is low toxic toward cells. CAY10621 has the potential for resistant cancer tumors research[1].
Product Specifications
CAS Number
120005-55-2
Product Name Alternative
SKI 5C
UNSPSC
12352005
Hazard Statement
H225, H319, H336
Target
SphK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cay10621.html
Concentration
22.95 mM * 100 μL in Methyl acetate
Purity
99.3
Solubility
10 mM in DMSO
Smiles
O=C(N1C(C)(C)OC[C@H]1C(C#CCCCCCCCCCCCCC)=O)OC(C)(C)C
Molecular Formula
C26H45NO4
Molecular Weight
435.64
Precautions
H225, H319, H336
References & Citations
[1]Lingkai Wong, et al. Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. J Med Chem. 2009 Jun 25;52 (12) :3618-26.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SphK1
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