Amino-Tri- (carboxyethoxymethyl) -methane (hydrochloride)

Amino-Tri- (carboxyethoxymethyl) -methane hydrochloride is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-Tri- (carboxyethoxymethyl) -methan hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

Product Specifications

CAS Number

[1416771-72-6]

UNSPSC

12352203

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amino-tri-carboxyethoxymethyl-methane-hydrochloride.html

Purity

97.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CCOCC(COCCC(O)=O)(COCCC(O)=O)N)O.Cl

Molecular Formula

C13H24ClNO9

Molecular Weight

373.78

References & Citations

[1]Markus Ribbert, et al. Self coupling recombinant antibody fusion proteins. WO2009013359A2.|[2]David Margulies, et al. Fluorescent molecular sensor for targeting changes in protein surfaces, and methods of use thereof. WO2015166491A2.