U92016A (hydrochloride)
U92016A hydrochloride is a potent, metabolically stable, orally acitive 5-HT1A receptor agonist with an exceptionally high degree of intrinsic activity[1][2]. U92016A hydrochloride binds with high affinity to human 5-HT1A receptors expressed in Chinese hamster ovary cells (Ki=0.2 nM) [2].
Product Specifications
CAS Number
149654-41-1
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/u92016a-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CCCN([C@H]1CC(C2=C(C=C3)NC(C#N)=C2)=C3CC1)CCC.Cl
Molecular Formula
C19H26ClN3
Molecular Weight
331.88
References & Citations
[1]A G Romero, et al. Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. J Med Chem. 1993 Jul 23;36 (15) :2066-74.|[2]R B McCall, et al. Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. J Pharmacol Exp Ther. 1994 Nov;271 (2) :875-83.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3
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