BMS-901715

BMS-901715 is a potent and selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 of 3.3 nM[1][2].

Product Specifications

CAS Number

[1699861-37-4]

UNSPSC

12352005

Target

AAK1

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bms-901715.html

Solubility

10 mM in DMSO

Smiles

OC1=CC(C2=NN(C(C)C)N=N2)=CC(NC3=NC=NN4C3=C(CN5CCC(N)CC5)C=C4)=C1

Molecular Formula

C22H28N10O

Molecular Weight

448.52

References & Citations

[1]Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358 (3) :371-86.|[2]Carolyn Diane Dzierba, et al. Pyrrolotriazine kinase inhibitors. WO2015054358A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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