MRS2693 (trisodium)
MRS2693 trisodium is a selective P2Y6 agonist with an EC50 value of 0.015 μM. MRS2693 trisodium can reduce the activation of NF-kappaB and activate the ERK1/2 pathway, and has a cytoprotective effect on mouse hindlimb skeletal muscle ischemia-reperfusion injury model[1][2].
Product Specifications
CAS Number
1448858-83-0
UNSPSC
12352005
Target
ERK; NF-κB; P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mrs2693-trisodium.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(NC(C(I)=C2)=O)=O)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O[Na])=O
Molecular Formula
C9H10IN2Na3O12P2
Molecular Weight
596.00
References & Citations
[1]Girard M, et al. Ligand-dependent intracellular trafficking of the G protein-coupled P2Y6 receptor. Biochim Biophys Acta Mol Cell Res. 2023 Jun;1870 (5) :119476.|[2]Mamedova LK, et al. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacol Res. 2008 Sep-Oct;58 (3-4) :232-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7069480 Inquire
Recombinant Saccharomyces cerevisiae Altered inheritance of mitochondria protein 34, mitochondrial (AIM34), partial
Sign In for Pricing
View Details 
MBS1146188-01 0.02 mg (E-Coli)
Recombinant Pseudomonas aeruginosa Chorismate synthase (aroC)
Sign In for Pricing
View Details MBS1146188-02 0.02 mg (Yeast)
Recombinant Pseudomonas aeruginosa Chorismate synthase (aroC)
Sign In for Pricing
View Details MBS1146188-03 0.1 mg (E-Coli)
Recombinant Pseudomonas aeruginosa Chorismate synthase (aroC)
Sign In for Pricing
View Details