Coformycin

Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity[1][2].

Product Specifications

CAS Number

[11033-22-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Deaminase; Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/coformycin.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1C2=C(NC=NC1)N(C=N2)[C@H]3[C@H](O)[C@H](O)[C@H](O3)CO

Molecular Formula

C11H16N4O5

Molecular Weight

284.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Coformycin.|[2]Lukey T, et al. S-adenosylhomocysteine hydrolase activity, deoxyadenosine triphosphate accumulation, and competence of thymocyte and spleen leucocyte response to mitogens in coformycin-treated mice. Biochem Pharmacol. 1983 Apr 15;32 (8) :1399-406.