Sonidegib metabolite M48
Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer Tmax (60 h) than Sonidegib[1].
Product Specifications
CAS Number
1221722-10-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sonidegib-metabolite-m48.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=C(C(C2=CC=C(C=C2)OC(F)(F)F)=CC=C1)C
Molecular Formula
C15H11F3O3
Molecular Weight
296.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Markus Zollinger, et al. Absorption, distribution, metabolism, and excretion (ADME) of ¹⁴C-sonidegib (LDE225) in healthy volunteers. Cancer Chemother Pharmacol. 2014 Jul;74 (1) :63-75.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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