Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

GW 9578

GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2].

Product Specifications

CAS Number

247923-29-1

UNSPSC

12352005

Hazard Statement

H225, H319, H336

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gw-9578.html

Concentration

20.30 mM * 50 μL in Methyl acetate

Purity

99.6

Solubility

10 mM in DMSO

Smiles

CC(C)(SC1=CC=C(CCN(C(NC2=CC=C(F)C=C2F)=O)CCCCCCC)C=C1)C(O)=O

Molecular Formula

C26H34F2N2O3S

Molecular Weight

492.62

Precautions

H225, H319, H336

References & Citations

[1]P J Brown, et al. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. J Med Chem. 1999 Sep 23;42 (19) :3785-8.|[2]Alexandre Trifilieff, et al. PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect. Br J Pharmacol. 2003 May;139 (1) :163-71.|[3]Dallas C Jones, et al. Nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is expressed in resting murine lymphocytes. The PPARalpha in T and B lymphocytes is both transactivation and transrepression competent. J Biol Chem. 2002 Mar 1;277 (9) :6838-45.

Shipping Conditions

Blue Ice

Storage Conditions

Solution, -20°C, 2 years

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PPARα

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Keratin 14 (KRT14) Antibody
abx002877-01 100 µL

Keratin 14 (KRT14) Antibody

Sign In for Pricing
View Details
Keratin 14 (KRT14) Antibody
abx002877-02 200 µL

Keratin 14 (KRT14) Antibody

Sign In for Pricing
View Details
Goat Polyclonal Goat anti-Rat IgG (H+L) Secondary Antibody [PE]
NB7112PE 1 mL

Goat Polyclonal Goat anti-Rat IgG (H+L) Secondary Antibody [PE]

Sign In for Pricing
View Details
GSK3B Rabbit Monoclonal Antibody [Clone ID: 23GB1250]
TA424820S 20 µL

GSK3B Rabbit Monoclonal Antibody [Clone ID: 23GB1250]

Sign In for Pricing
View Details
HES4 (Hairy Family Helix-loop-helix Transcription Factor)
MBS613639-01 0.1 mg

HES4 (Hairy Family Helix-loop-helix Transcription Factor)

Sign In for Pricing
View Details
HES4 (Hairy Family Helix-loop-helix Transcription Factor)
MBS613639-02 5x 0.1 mg

HES4 (Hairy Family Helix-loop-helix Transcription Factor)

Sign In for Pricing
View Details