L-threo-Sphingosine
L-threo-Sphingosine is a potent MAPK inhibitor. L-threo-Sphingosine induces apoptosis and clear DNA fragmentation. L-threo-Sphingosine shows anticancer effect[1].
Product Specifications
CAS Number
[25695-95-8]
Product Name Alternative
L-threo-Sphingosine C-18
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-threo-sphingosine.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCCCCCCC/C=C/[C@H](O)[C@@H](N)CO
Molecular Formula
C18H37NO2
Molecular Weight
299.49
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Sakakura C, et al. Selectivity of sphingosine-induced apoptosis. Lack of activity of DL-erythyro-dihydrosphingosine. Biochem Biophys Res Commun. 1998 May 29;246 (3) :827-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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