L-threo-Sphingosine
Product Specifications
UNSPSC Description
L-threo-Sphingosine is a potent MAPK inhibitor. L-threo-Sphingosine induces apoptosis and clear DNA fragmentation. L-threo-Sphingosine shows anticancer effect[1].
Target Antigen
Apoptosis; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis;MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-threo-sphingosine.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCCCCCCC/C=C/[C@H](O)[C@@H](N)CO
Molecular Weight
299.49
References & Citations
[1]Sakakura C, et al. Selectivity of sphingosine-induced apoptosis. Lack of activity of DL-erythyro-dihydrosphingosine. Biochem Biophys Res Commun. 1998 May 29;246(3):827-30.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117152/L-threo-Sphingosine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117152/
Clinical Information
No Development Reported
CAS Number
25695-95-8
Curated Selection
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