DCG066

DCG066 is an inhibitor of lysine methyltransferase G9a. DCG066 can bind directly to G9a and inhibit methyltransferase activity in vitro. DCG066 decreases di-methylation levels of histone H3 lysine 9 (H3K9Me2), inhibits cell proliferation and induces cell apoptosis. DCG066 displays low cytotoxicity in leukemia cell lines with high levels of G9a expression, including K562[1].

Product Specifications

CAS Number

[494786-13-9]

UNSPSC

12352005

Target

Apoptosis; Histone Methyltransferase

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dcg066.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C)C)NC1=CC=C(C=C1)CN2CCC(CC2)C(O)(C3=CC=C(C=C3)C(F)(F)F)C4=CC=C(C=C4)C(F)(F)F

Molecular Formula

C30H31F6N3O2

Molecular Weight

579.58

References & Citations

[1]Kondengaden SM, et al. Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines. Eur J Med Chem. 2016 Oct 21;122:382-393.