(±) -Penbutolol-d9 (hydrochloride)

(±) -Penbutolol-d9 (hydrochloride) is a deuterium labeled (±) -Penbutolol hydrochloride. (+) -Penbutolol hydrochloride is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1].

Product Specifications

CAS Number

[1346605-01-3]

Product Name Alternative

(Rac) -Penbutolol-d9 (hydrochloride) ; (±) -Isopenbutolol-d9 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

Adrenergic Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Cardiovascular Disease

Solubility

10 mM in DMSO

Smiles

OC(CNC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])COC1=CC=CC=C1C2CCCC2.[H]Cl

Molecular Formula

C18H21D9ClNO2

Molecular Weight

336.94

Precautions

P264-P270-P330-P501

References & Citations

[1]Chen M, et al. Effects of beta-adrenoceptor antagonists on Ca (2+) -overload induced by lysophosphatidylcholine in rat isolated cardiomyocytes. Br J Pharmacol. 1996 Jun;118 (4) :865-70.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.