(-) -Penbutolol

(-) -Penbutolol ((S) -Penbutolol) is a potent β-adrenoceptor and 5-HT receptor antagonist with Ki values of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3[1][2].

Product Specifications

CAS Number

[38363-40-5]

Product Name Alternative

(S) -Penbutolol; (-) -Isopenbutolol

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

5-HT Receptor; Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/minus-penbutolol.html

Solubility

10 mM in DMSO

Smiles

O[C@H](COC1=CC=CC=C1C2CCCC2)CNC(C)(C)C

Molecular Formula

C18H29NO2

Molecular Weight

291.43

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Hjorth S, et al. In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-) penbutolol. J Pharmacol Exp Ther. 1993 May;265 (2) :707-12.|[2]M E Castro, et al. Affinity of (±) -Pindolol, (-) -Penbutolol, and (-) -Tertatolol for Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Human and Rat Brain. Journal of Neurochemistry, Volume 75, Issue 2, p. 755-762.|[3]Gartside SE, et al., Effects of (-) -tertatolol, (-) -penbutolol and (+/-) -pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. Br J Pharmacol. 1999 May;127 (1) :145-52.