Inz-1

Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM) . Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans[1].

Product Specifications

CAS Number

[897776-15-7]

UNSPSC

12352005

Hazard Statement

H302

Target

Cytochrome P450; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/inz-1.html

Solubility

10 mM in DMSO

Smiles

O=C(OC)CN1N=C(C2=CC=CC=C2)C3=C1C=CC=C3

Molecular Formula

C16H14N2O2

Molecular Weight

266.29

Precautions

P264-P270-P330-P501

References & Citations

[1]Benjamin M Vincent, et al. A Fungal-Selective Cytochrome Bc 1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.Cell Chem Biol. 2016 Aug 18;23 (8) :978-991.