Inz-1
Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans[1].
Product Specifications
CAS Number
897776-15-7
UNSPSC
12352005
Hazard Statement
H302
Target
Cytochrome P450; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/inz-1.html
Solubility
10 mM in DMSO
Smiles
O=C(OC)CN1N=C(C2=CC=CC=C2)C3=C1C=CC=C3
Molecular Formula
C16H14N2O2
Molecular Weight
266.29
Precautions
P264-P270-P330-P501
References & Citations
[1]Benjamin M Vincent, et al. A Fungal-Selective Cytochrome Bc 1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.Cell Chem Biol. 2016 Aug 18;23 (8) :978-991.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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