AHR-5333

AHR-5333 is a selective human blood neutrophil 5-lipoxygenase inhibitor. AHR-5333 exhibits potent, long-acting activity in rat and guinea pig in vivo models of immediate hypersensitivity[1].

Product Specifications

CAS Number

[60284-71-1]

UNSPSC

12352005

Target

Lipoxygenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/ahr-5333.html

Solubility

10 mM in DMSO

Smiles

CC(C1=CC=C(C(OC)=C1)OCCCN2CCC(CC2)C(C3=CC=C(C=C3)F)(O)C4=CC=C(C=C4)F)=O

Molecular Formula

C30H33F2NO4

Molecular Weight

509.58

References & Citations

[1]J M Yanni, et al. Effects of AHR-5333, a new potential antiallergy compound, in in vivo models of immediate hypersensitivity. Int Arch Allergy Appl Immunol. 1988;85 (4) :428-33.|[2]G. Graff, et al. 1-[4-[3-[4-[Bis (4-fluorophenyl) hydroxymethyl]-1-piperidinyl] propoxy]-3]-methoxyphenyl] ethanone (AHR-5333) : A selective human blood neutrophil 5-lipoxygenase inhibitor. Prostaglandins. Volume 38, Issue 4, October 1989, Pages 473-496