What is the catalog number for α5IA?

The catalog number for α5IA is HY-116622.

What sizes are available for α5IA?

α5IA is available in the following size(s): 5 mg, 10 mg.

How many pack sizes does α5IA come in?

α5IA is available in 2 different pack sizes.

α5IA is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures α5IA?

α5IA is manufactured by QuantiMol.

What is the estimated delivery time for α5IA?

Estimated delivery time for α5IA is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for α5IA?

The safety data sheet for α5IA is available here: http://file.medchemexpress.com/batch_PDF/HY-116622/α5IA-SDS-MedChemExpress.pdf.

α5IA

α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential[1].

Product Specifications

CAS Number

215874-86-5

Product Name Alternative

L-822179

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α5ia.html

Purity

97.33

Solubility

DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN1N=NC(COC(C2=C3C=CC=C2)=NN4C3=NN=C4C5=NOC(C)=C5)=C1

Molecular Formula

C17H14N8O2

Molecular Weight

362.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Chitra Vinnakota, et al. An 5 GABAA Receptor Inverse Agonist, 5IA, Attenuates Amyloid Beta-Induced Neuronal Death in Mouse Hippocampal Cultures. Int J Mol Sci. 2020 May 6;21 (9) :3284. |[2]Arnaud Duchon, et al. Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5-selective GABAA inverse agonist. Br J Pharmacol. 2020 Mar;177 (5) :1106-1118.